Liver Cancer Stem Cells
نویسندگان
چکیده
منابع مشابه
Liver Cancer Stem Cells
Hepatocellular carcinoma is the most common primary malignancy of the liver in adults. It is also the fifth most common solid cancer worldwide and the third leading cause of cancer-related death. Recent research supports that liver cancer is a disease of adult stem cells. From the models of experimental hepatocarcinogenesis, there may be at least three distinct cell lineages with progenitor pro...
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Cancer stem cells (CSCs) have been identified as rare cellular populations in many cancers, including leukemia and solid tumors. This minor subpopulation of cancerous cells is immortal tumor-initiating cells which thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug/radiation resistance. Low proliferative rate, high self-renewing capacity, differentiatio...
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The presence of somatic stem cells, which have high proliferative capacity, multipotency (capacity to differentiate into multiple mature cells with different functions) and self-renewal capacity (capacity to maintain the stem cells as themselves by asymmetric division) has been gradually revealed in various digestive organs such as intestines and liver. Although researchers used to be intereste...
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Studies of aggregation chimaeras and X-linked polymorphisms strongly suggest that liver tumours are derived from single cells (monoclonal), but the important question is, which cell? Stem cell biology and cancer are inextricably linked. In continually renewing tissues such as the gut mucosa and epidermis, where a steady flux of cells occurs from the stem cell zone to the terminally differentiat...
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Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. The concept of cancer stem cells (CSCs) is based primarily on the clinical and experimental observations that indicate the existence of a subpopulation of cells with the capacity to self-renew and differentiate as well as show increased resistance to radiation and chemotherapy. They are considered as the fact...
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ژورنال
عنوان ژورنال: Trakya University Journal of Natural Sciences
سال: 2019
ISSN: 2147-0294
DOI: 10.23902/trkjnat.486558